UGENE, A NEWLY IDENTIFIED PROTEIN THAT IS COMMONLY OVER- EXPRESSED IN CANCER, AND THAT BINDS URACIL DNA-GLYCOSYLASE by
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چکیده
We hereby approve the thesis/dissertation of Chunguang Guo candidate for the Ph.D. degree *. (date) 06/24/08 *We also certify that written approval has been obtained for any proprietary material contained therein. Table 1-1 DNA repair genes linked to familial cancer syndromes……….……19 Table 2-1 Difference between Ugene-p and Ugene-q…………………….……31 Table 2-2 Ratio of Ugene-p and Ugene-q in colon cancer cell lines……………34 Table 2-3 Ratio of Ugene-p and Ugene-q in V330 ……………………….……41
منابع مشابه
Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase.
Expression microarrays identified a novel transcript, designated as Ugene, whose expression is absent in normal colon and colon adenomas, but that is commonly induced in malignant colon cancers. These findings were validated by real-time PCR and Northern blot analysis in an independent panel of colon cancer cases. In addition, Ugene expression was found to be elevated in many other common cance...
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